1 results
5 - Developmental Origins of Neurobiological Vulnerability for PTSD
-
- By Rosemary Bagot, Graduate student Neuroscience, McGill University, Montréal, Québec, Carine Parent, Graduate student Neurological Sciences Program, McGill University, Montréal, Québec, Timothy W. Bredy, Postdoctoral Fellow Department of Psychiatry and Biobehavioral Sciences and Brain Research Institute, University of California, Los Angeles, Tieyuan Zhang, Postdoctoral Fellow Program for the Study of Behaviour, Genes and Environment, McGill University, Montréal, Québec, Alain Gratton, Associate Professor Department of Psychiatry, McGill University; Researcher, Douglas Hospital Research Centre, Montréal, Québec, Michael J. Meaney, James McGill Professor of Medicine Departments of Psychiatry and Neurology and Neurosurgery; Director Program for the Study of Behaviour, Genes and Environment, McGill University; Associate Director of Research Researcher, Douglas Hospital Research Centre, Montréal, Québec
- Edited by Laurence J. Kirmayer, McGill University, Montréal, Robert Lemelson, University of California, Los Angeles, Mark Barad, University of California, Los Angeles
-
- Book:
- Understanding Trauma
- Published online:
- 27 July 2009
- Print publication:
- 15 January 2007, pp 98-117
-
- Chapter
- Export citation
-
Summary
The question of vulnerability lies very much at the heart of research on anxiety disorders, such as PTSD (Yehuda, Schmeidler, Wainberg, Binder-Brynes, & Duvdevani, 1998). Surprisingly, only a minority (∼25–30%) of humans subjected to even such a profound trauma as rape develop PTSD (Ressnick, Kilpatrick, Dansky, Saunders, & Best, 1993), and early family life serves as a highly significant predictor of vulnerability to PTSD following trauma (Udwin, Boyle, Yule, Bolton, & O'Ryan, 2000). Moreover, many cases of PTSD derive from events that might not be considered as necessarily traumatic by the general population (Breslau et al., 1998), a finding that further underscores the importance of vulnerability. Moreover, there is evidence for the familial transmission of vulnerability to PTSD that is related to alterations in parent–offspring interactions. These findings are not surprising because anxiety reduces parental responsiveness to offspring (e.g., Fleming, 1988, 1999). These findings suggest that early life events might alter the development of neural systems that mediate cognitive and emotional responses to trauma, and thus contribute to individual differences in vulnerability to PTSD.
The question can be rendered more precise in light of the remarkable advances in human clinical studies. First, PTSD research suggests that the probability of chronic PTSD following trauma is related to the magnitude of the initial reaction to the event (Shalev, this volume). Hence, factors that influence the development of individual differences in reactivity are likely of considerable relevance.